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Projects
Projects
Alternative methods and eco-relevance
ECO8: Development of a strategy to predict acute fish lethality using fish cell lines and fish embryos
ECO8.2: Initial explorations on alternatives for fish chronic toxicity testing
Chemical Carcinogenesis
CC1-FOAR: Development of Criteria for Threshold Genotoxins: Interactions of Chemical Carcinogens With Cytoskeletal Macromolecules
CC1-UNEW/ZENE: Molecular Toxicology and Structure Activity Relationships in the Rodent Carcinogenesis of Industrially Important Dienes and the Relevance for Human Cancer
CC1-USTR: Interspecies Differences in the Metabolism of Toxic Aldehydes and Ketones by the AKR7 Family of Aldo-Keto Reductases
CC2-LUMC: Gene Expression Profiling in DNA Repair-Deficient XPA Transgenic Mice Following Treatment With Benzo[A]Pyrene and Cyclosporin-A: Lymphomagens with Different Modes of Action
CC2-MRCT: Gene Expression Profiling of Skin Carcinogenesis in Mice Using cDNA Microarrays
CC2-UNBI: Determination of Human and Rodent Gene Expression Patterns in Response to Chemical Carcinogens: Facilitation of Knowledge-Based Human Risk Assessment From Molecular Mechanisms
CC2-001-UMAN: Quantitative Associations Between DNA Adduct Levels and Mutations: a Tool for Human Risk Assessment
CC2-001-UWSW: Dose Relationships of DNA Adducts and Mutations
CC2-001-FSBW: Evaluation of Chemically-Induced Genotoxicity as an Increment to Background DNA Damage and Spontaneous Mutagenesis
CC3-ICL: Assessment of risk factors influencing trends in incidence of female breast carcinoma
Consumer Exposure
A3.1: Establishment and Management of a Research Inventory on the Indoor Environment (IERIE)
A3.3: The EXPOLIS-Index Study, Human Exposure Patterns for Health Risk Assessment:Indoor Determinants of Personal Exposures in the European Expolis Population in Athens, Basel, Grenoble, Milan, Helsinki, Oxford And Praha
C1.3: Establish a Database of a Number of Parameters Sufficient Relevant for Reliable Prediction of European Consumer Exposures
C1.5: European Sourcebook of Information Describing Human Exposures to Chemicals in the Environment (ExpoFacts)
D1.1-SYNG: Study of the Role and Application of Biomarkers in the Management of the Health Risks Associated with Occupational Exposures to Chemicals
D2.1-MRCI: Background Incidence of Key Biomarkers of Chemical Exposure within the General Population
A2.3: International Workshop on Methods to Determine Dermal Permeation for Human Risk Assessment
C1.6: Possibilities and capabilities of 3D-body-scanning systems for the purpose of risk assessment.
D1.1-NOFE: Biomarkers of Exposure - Trends and Key Developments
B5-CERTH: Realistic estimation of exposure to substances from multiple sources (TAGS)
B4-THL: Integrated exposure for risk assessment in indoor environments
C2.2-HPAG: Description of the nature of the accidental misuse of chemicals and chemical products
Databases, Modelling & Validation
Q2-MN: Overcoming current Limitations In Metabolism Prediction of Industrial Chemicals (OLIMPIC)
ECO4-RIVO: MonitoringBase. Collation and Evaluation of Monitoring Programmes and Measured Environmental Concentration Data on Organic Chemicals in European Aquatic Environments
ECO3B-DELFT: Generic Estuary Modelling System to Evaluate Transport, Fate and Impact of Contaminants (GEMCO)
EEM3-UDUR: Terrestrial Runoff Modeling for Risk Assessment of Chemical Exposure (TERRACE)
EEM6-TECH: Develop a Concept for Externalising Databases From Arcview Which is Needed for GREAT-ER 2.0 to Allow a Full Pan-European Development
EEM6-UCRA: Constructing a Sediment Exposure Module in GREAT-ER
EEM6-INTE: Development of the GREAT-ER II Extension Sediment Exposure Module
ECO3A-TUHH: MarSens – How Should We Deal with the Uncertainty in the Extrapolation of the Sensitivity of Marine Organisms to Narcotics? Critical Review of the State of the Art of Marine Risk Assessment and Recommendations for Future Research
EEM9-PGEU: Quantitative Structure-Activity Relationships software for data management
ECO3A-UTO: Evaluating Multi-Media Fate and Transport models on a Regional and Global Scale
ECO3A.2: Creation, Evaluation and Application of an Integrated Environmental Fate and Human Food Chain Bioaccumulation Model for Polar and Non-polar Organic Substances (IMPS)
ECO15-USTO: Rapid estimation of TMF using laboratory, field and computer modelling methods in aquatic organisms
ECO16-IRAS: Generate a validated CBR database and validate a CBR chronic toxicity range for narcotics
ECO14bis-UNT: Alternative methodology for standard laboratory fish bioconcentration tests
ECO12: Validation Chemicals for Assessing Biodegradation Tests
ECO11: Towards rationally designed hazard, risk and persistency assessment: Putting the “bio” back into biodegradability tests
ECO10: EPOCH - Evaluation of existing population models for their potential application in ecological risk assessment of chemicals
ECO14-USTO: Development and validation of an abbreviated in vivo fish bioconcentration test
Environment & Wildlife
EMSG21: Endocrine Disruption in the Marine Environment (EDMAR)
EMSG22: Endocrine Disruption in the Aquatic Environment; Laboratory Investigation of Endocrine-Active Chemicals
EMSG23: Endocrine Modulating Effects in Fish Along the Elbe River and in Reference Areas. Assessment of Risks Related to the Habitat Conditions and the Natural Variability of Endocrine Functions
EMSG27: Environmental Effects on Uterine Tissues of Baltic Seals With Special Emphasis on Organochlorines and Uterine Leiomyomas
EMSG28: Development, Validation and Application of in Vitro and in Vivo Test Systems for Non-Oestrogenic Endocrine Disrupting Chemicals in Wildlife
EMSG36: Further Development and Scientific Evaluation of Appropriate Methods for Identification and Characterisation of Toxic Effects of Hormonally Active Substances on Reproduction in Birds as Part of Multi-Generation-Studies
EMSG38: Review of the Relative Contribution of Industrial Chemicals, Compared to Steroids, in Causing the Sexual Disruption in Wild Fish Populations
EMSG42: Increase of the robustness of the fish endocrine assay and avoidance of irrelevant endpoints
EMSG43: Endocrine disrupting effects in fish induced by parasites
Human Biomonitoring
D1.1-SYNG: Study of the Role and Application of Biomarkers in the Management of the Health Risks Associated with Occupational Exposures to Chemicals
D2.1-MRCI: Background Incidence of Key Biomarkers of Chemical Exposure within the General Population
D2.2-VITO: Generation and Application of a Model to Determine Intra- and Inter-individual Variation in Biomarkers
HBM1-UCRA: A Framework for the Development and Application of Environmental Biological Monitoring Guidance Values
HBM2-DOW: Development of a Tiered Set of Modelling Tools for Derivation of Biomonitoring Guidance Values
HBM2-ITC: Development of a computer program with a multi-level modelling tool for the estimation of biomonitoring equivalent guidance values for chemical agents related to health based exposure rates for inhalation, oral intake and/or skin exposure.
HBM3: Data on in vitro metabolism and mechanisms of action in combination with kinetic modelling: integrating in risk assessment
EMSG54: Advancing Neurodevelopmental Evaluation in Children: An Interdisciplinary Scientific Approach
Nanotechnology Testing
N1-FRAU: Tiered Approach to Testing and Assessment of Nanomaterial Safety to Human Health
N2-YORK: Detection, Fate and Uptake of Engineered Nanoparticles in Aquatic Systems
N3-TNO: Testing and Assessment of Reproductive Toxicity of Nanomaterials
S1-WAG: Safety Perceptions of New Technologies (SPOT) – making social and natural sciences meet
Persistence, Bioaccumulation and Toxicity
ECO1A-INIA: Relationships Between Persistence, Bioaccumulation Potential and Effects in Waters, Sediments and Soils
ECO1B-WRCN: Comparison of Marine and Freshwater Data and Test Methods Review of Literature – Phase I
ECO1C-TUD: Comparison of Soil and Sediment Ecotoxicity Data and Test Methods
ECO2A-ASTRA: Understanding and Measurement of Persistence in the Marine and Terrestrial Compartments
ECO3A-UTO: Evaluating Multi-Media Fate and Transport models on a Regional and Global Scale
MISTRA: A New Strategy for the Risk Management of Chemicals: MISTRA and Persistence
ECO6-CSL: Identifying Transgeneric Biotransformational Potential
ECO7: Development of a Reference Database (Bioconcentration Factors, BCF)
Release & Uncertainty
EEM1-ASTRA: Identification and Evaluation of Emission Databases in Europe
EEM4: Development of Tools for Probabilistic Uncertainty Analysis in Environmental Risk Assessment of Chemicals
Reproductive Health
EMSG29: Examination of Bull Sperm as a Sentinel Species for Male Reproductive Health
EMSG8: Are Connexins, the Gap Junctional Integral Proteins, Involved in Male Reproductive Disorders Associated With Possible Exposure to Endocrine Disrupting Agents?
EMSG9: Development of a Sensitive Assay for Androgenic Activity Using Prostate Cells Lines
EMSG10: Do Industrial Oestrogens or Their Metabolites Influence Male Reproductive Function?
EMSG11: Sperm Quality Studies Measuring Seminiferous Tubules
EMSG12: Exposure to Endocrine-Disruptor Chemicals Assessed by Ligand-Receptor Interaction Analysis of Human Body Fluids
EMSG16: Epidemiological Studies of Endocrine Disruptors and Human Health
EMSG17: Identification of Biomedical Endpoints of Oestrogen Action in the Male Rat With Possible Confirmation in Primate Model and in Man
EMSG19: Chemicals and Pregnancy Study-UK (CHAPS-UK): Multicentre Study of Occupational Exposure to Chemicals and Male Fertility
EMSG20: Environmental Factors and Male Reproductive Functions. A Cohort Study of the Incidence of Cryptorchidism and Hypospadia in 5000 Newborn Boys in the Rotterdam Area
EMSG25: Comparative Developmental and Reproductive Toxicity of Endocrine Disrupting Chemicals in Vivo Rat Model
RTD-INSERM: Neuroendocrine Effects of Endocrine Active Chemicals (EAC): a Literature Review
EMSG46: Characterization of testicular toxicity using traditional and omic tools
Respiratory Toxicity
IA4.6: A Rat IGE Test for the Identification of Chemical Respiratory Allergens
R2-TNO: The Role of Irritancy and Irritant-Induced Inflammation in the Elicitation of Respiratory Hypersensitivity Reactions
R2-BIHH: The Physiological and Bronchial Inflammatory Marker Response to Exposure in the Workplace in Patients With Occupational Asthma
IRTA2-001-SYNG: Transcript Profiling and Cytokine Fingerprinting : Identification and Characterisation of Chemical Respiratory Allergens
IRTA2-001-TNOV: Characterisation of Respiratory Tract Sensitization to Improve Hazard Identification of Respiratory Allergens
IRTA2-001-VITO: In Vivo and In Vitro Characterisation of Chemical Respiratory Allergens: Development of an In Vitro Assay Using Gene Expression Profiling
IRTA2-001-HSL: Development of a Human In Vitro Testing Model to Distinguish Immune Responses to Chemical Respiratory vs Contact Allergens
Testing Strategies and Risk Assessment
EMSG39-BAHE: Assessment of biological variability in mice – Development of a draft protocol
EMSG24: Environmental Oestrogens and the Neuro-Endocrine Regulation of Reproduction of Fish
EMSG7: Screening Test in Fish - Aquatic Toxicity Project A
EMSG31: Aquatic Invertebrates Study - Aquatic Toxicity Project C
EMSG13: Genetic Sex Determination of Fish - Aquatic Toxicity Project D
EMSG34A: Validation of the OECD protocol for the surgical castrate rat (Hershberger) assay
EMSG34B: Validation of the OECD Protocol for the Rat Uterotrophic assay
EMSG35-BASF: Enhanced OECD TG 407 - Development and Validation
EMSG33: Chemical Repository
21DAY: Phase 3 of the validation of the OECD Fish Screening Assay
EMSG30B1: Evaluation of Fish Development Test
EMSG30B2: Evaluation of Fish Reproduction Test
EMSG34.4: Validation of the OECD protocol for the rodent Hershberger bioassay with the stimulated weanling male
B6-DOW: Improved hazard assessment of chemical sensitizers through testing of novel markers
EMSG44: Impact of physiological, lifestyle and environmental factors on the development of puberty
ECO13: Development, application and evaluation of model-based screening procedures for PBT chemicals and POPs (SCREEN-POP)
AIMT1-PG: Evaluation of Signal Transduction Pathways in Model Organisms as Critical Mediators of Developmental Toxicity
EMSG37-BAYER: Participation of Bayer CropScience in Phase 1A and 1B of the OECD validation work on the “Non-Spawning Fish Screening Assay” for the detection of endocrine active substances according to the OECD test protocol (ENV/JM/TG/EDTA(2002)5)
Tiered Risk Assessment
EMSG52-MRC: Steroidogenesis and inter species comparison literature review
B1.1-FRAU: Identification of Structure Activity Relationships Alerts for Substances With Low NOELs (REPDOSE)
B2.1-TNO: Characterisation of Uncertainty and Variation in Assessment of Chronic Occupational Exposure
B2.2-FoBiG: Provide Examples Where Risk Characterisations can be Conducted With the Existing and Possible Inadequate Data Sets
B2.3-IOM: Variability and Uncertainty in Chemical Exposures for Regulatory Risk Assessment
B3.7-HSL: The Rapid Generation And Analysis of Physiologically-Based Pharmacokinetic Models (PBPK Model)
B3.3: The Intake Fraction (iF) concept: modelling, expansion and application tests
EEM2: Validation of the Risk Assessment Module Against Observations and Against Other Models in the Context of EMEP POP Modelling Intercomparison Study
EMSG47-WCA: Support a tiered approach to evaluate endocrine effects in aquatic organisms
Toxicogenomics
EMSG49-CNRS: Reprogramming of DNA methylation during mammalian development and environmental impact of Endocrine Disruptors
Workplace Exposure
A1.2-UNAB: Database Of European Workplace Exposure Research Activities (HEROX)
A1.3-UNAB: Development Of A Database For Workplace Exposure Measurements
A2.1: Literature Survey On Dermal Deposition In The Chemical Industry
A2.2-UNJM: Determination of the Optimal Physico-Chemical Parameters to Use in a QSAR Approach to Predict Skin Permeation Rate
D1.1-NOFE: Biomarkers of Exposure Trends and Key Developments
A2.5-TNO: Evaluation of Real and Theoretical Effectiveness of Skin Protection Equipment
IRTA2-002-UUIR: Heterogeneity in Response to Iso-Cyanate Exposure in the Work Environment
A1.3-IOM: Establish the Framework and Operating system for a Cefic Database (CEMAS)
B3.1-CUSS: Strategies for Success? Managing Chemical Risks in Small Workplaces: a Review of European Practice
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